Scientific
PUBLICATIONS
Articles (*denotes equal contribution)
*Simkin, J., *Aloysius, A., Adam, M., Safaee, F., Donahue, R.R., Biswas, S., Lakhani, Z., Gensel, J.C., Thybert, D., Potter, S., and †Seifert, A.W. (2024) Tissue resident macrophages specifically express Lactotransferrin and Vegfc during complex tissue regeneration in spiny mice. Developmental Cell. https://doi.org/10.1016/j.devcel.2023.12.017
*†Seifert, A.W., *Duncan, E.M., and *Zayas, R.M. (2023) Enduring questions in regenerative biology: searching for answers. Communications Biology. pdf
Haghani, A., … Seifert, A.W. …Horvath, S. (180 authors) (2023) DNA Methylation Networks Underlying Mammalian Traits. Science 381, no. 6658 (2023): eahttp://www.walla.co.ilbq5693.
Lu, A.T., …Seifert, A.W… Horvath, S. (190 authors) (2023). Universal DNA methylation age across mammalian tissues. Nature Aging. https://doi.org/10.1038/s43587-023-00462-6.
Tomasso, A, Koopmans, T. Lijnzaad, P. Bartscherer, K. and †Seifert A.W. (2023) An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys). Science Advances 9, no. 17 (2023): eadf2331. DOI: 10.1126/sciadv.adf2331
Powell J.M., Inoue K., Wallace K.J., Seifert A.W., Young L.J., Kelly A.M. (2022). Distribution of vasopressin 1a and oxytocin receptor protein and mRNA in the basal forebrain and midbrain of the spiny mouse (Acomys cahirinus). Brain Structure and Function. Oct. 21. doi: 10.1007/s00429-022-02581-z.
Sarthak Sinha*, Holly D. Sparks*, Elodie Labit, Hayley N. Robbins, Kevin Gowing, Arzina Jaffer, Eren Kutluberk, Rohit Arora, Micha Sam Brickman Raredon, Leslie Cao, Scott Swanson, Peng Jiang, Olivia Hee, Hanna Pope, Matt Workentine, Kiran Todkar, Nilesh Sharma, Shyla Bharadia, Keerthana Chockalingam, Luiz G. N. de Almeida, Mike Adam, Laura Niklason, S. Steven Potter, Ashley W. Seifert, Antoine Dufour, Vincent Gabriel, Nicole L. Rosin, Ron Stewart, Greg Muench, Robert McCorkell, John Matyas, Jeff Biernaskie. (2022). Fibroblast inflammatory priming determines regenerative versus fibrotic skin repair in reindeer. Cell 185, no. 25: 4717-4736. pdf
Gonzalez Abreu J.A, Rosenberg A.E, Fricker B.A, Wallace K.J, Seifert A.W., Kelly A.M. (2022). Species-typical group size differentially influences social reward neural circuitry during nonreproductive social interactions. iScience. May 20;25(5):104230. doi: 10.1016/j.isci.2022.104230. pdf
Duerr, T. J., Jeon, E. K., Wells, K. M., Villanueva, A., Seifert, A.W., McCusker, C. D., & Monaghan, J. R. (2022). A constitutively expressed fluorescent, ubiquitination-based cell cycle indicator (FUCCI) in axolotls for studying tissue regeneration. Development. Mar 15;149(6):dev199637. doi: 10.1242/dev.199637. pdf
*Peng, H., *Shindo, K., Donahue, R.R., Ahern, B.M., Levitan, B.M., †Satin, J., †Seifert, A.W. and †Abdel-Latif, A., (2021). Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction. Nature Regenerative Medicine doi: 10.1038/s41536-021-00186-4. pdf
Purushothaman S, Lopez Aviña B.B, †Seifert A.W. (2022). Sonic hedgehog is Essential for Proximal-Distal Outgrowth of the Limb Bud in Salamanders. Front Cell Dev Biol. 10:797352. doi: 10.3389/fcell.2022.797352. eCollection 2022.
†Seifert, A.W. and Temple-Smith, P. (2022). A remarkable rodent: regeneration and reproduction in spiny mice (Acomys). Current Topics in Developmental Biology, Emerging Model Systems. pdf
Fricker, B.A., Seifert, A.W., and Kelly, A.M. (2021). Characterization of Social Behavior in the Spiny Mouse (Acomys cahirinus). Ethology. doi.org/10.1111/eth.13234
Kelly, A.M., and Seifert, A.W. (2021). Distribution of vasopressin and oxytocin neurons in the forebrain of male and female spiny mice (Acomys cahirinus): widespread sex differences in the oxytocin system. Neuroscience. doi.org/10.1016/j.neuroscience.2021.05.034. pdf
Aloysius, A., Saxena, S., & †Seifert, A.W. (2020). Metabolic regulation of innate immune cell phenotypes during wound repair and regeneration. Current Opinion in Immunology, 68, 72-82. pdf
Wong, W., Kim, A., Seifert, A.W., Maden, M., & Crane, J. D. (2020). Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis. PLoSOne, 15(10): e0241617. https://doi.org/10.1371/journal.pone.0241617
Gawriluk, T.R., Simkin, J., Hacker, C.K., Kimani, J.M., Kiama, S.G., Ezenwa, V.O., and †Seifert, A.W. (2020). Mammalian musculoskeletal regeneration is associated with reduced inflammatory cytokines and an influx of T cells. Frontiers in Immunology, 11 1695. https://www.frontiersin.org/articles/10.3389/fimmu.2020.01695/full
Gredler, M. L., Patterson, S. E., Seifert, A.W., and Cohn, M. J. (2020). Foxa1 and Foxa2 orchestrate development of the urethral tube and division of the embryonic cloaca through an autoregulatory loop with Shh. Developmental Biology 465, 23-30. DOI: 10.1016/j.ydbio.2020.06.009
Dunoyer, L., †Seifert, A.W., and †Van Cleve, J. (2020). Evolutionary bedfellows: Reconstructing the ancestral state of autotomy and regeneration. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. https://doi.org/10.1002/jez.b.22974. pdf
Wang, C., Guerriero, L. E., Ajwad, A. A., Huffman, D. M., Brooks, T. C., Sunderam, S., Seifert, A.W., and O’hara, B. F. (2020). A comparative study of sleep and diurnal patterns in house mouse (Mus musculus) and Spiny mouse (Acomys cahirinus). Scientific Reports 10:10944. pdf
Meador, W.D., Story, H.M., Seifert, A.W., Bersi, M.R., Buganza, A.T., Rausch, M.K. (2019). The Regional-Dependent Biaxial Behavior of Aging Mouse Skin: A Detailed Histomechanical Characterization, Residual Strain Analysis, and Constitutive Model. Acta Biomaterialia 101, 403-413. pdf
Saxena, S., Vekaria, H., Sullivan, P.G., and †Seifert, A.W. (2019). Connective tissue fibroblasts from highly regenerative mammals are refractory to ROS-induced cellular senescence. Nature Communications 10(1), 1-16. pdf
Purushothaman, S. Elewa, A., and †Seifert, A.W. (2019). Fgf-signaling is compartmentalized within the mesenchyme and controls proliferation during salamander limb development. eLife 8: e48507. doi: 10.7554/eLife.48507
†Seifert, A. W., Cook, A. B., and Shaw, D. (2019). Normal skin development in salamanders reveals two routes to skin regeneration. Developmental Biology. doi:10.1016/j.ydbio.2019.07.001. pdf link
Cyr, J. L., Gawriluk, T. R., Rada, B., Wendy T. Watford, W. T., Seifert, A. W., and Ezenwa, V. O. (2019). Comparison of neutrophils from a regeneration-competent and incompetent mammal reveals subtle differences in cell quantity and function. Integrative and Comparative Biology, p.1-12. doi.org/10.1093/icb/icz023. pdf
Simkin, J. and †Seifert, A.W. (2017). Translating regenerative biology into clinically relevant therapies: are we on the right path? Stem Cell Translational Medicine. http://dx.doi.org/ 10.1002/sctm.17-0213. pdf
†Seifert, A.W., and Muneoka, K. (2017). The blastema and epimorphic regeneration in mammals. Developmental Biology 433 (2018) 190–199. pdf
Simkin, J., Gawriluk, T.R., Gensel, J., and †Seifert, A.W. (2017). Epimorphic regeneration in spiny mice requires cellular inflammation and immunity. eLife . DOI: 10.7554/eLife.24623. pdf
Cook, A.B., and †Seifert, A.W. (2016). Beryllium nitrate inhibits fibroblast migration to disrupt epimorphic regeneration. Development 143, 19: 3491-3505. doi: 10.1242/dev.134882
Leung, M.C.K, Hutson, M. Shane, Seifert, A.W., Baker, N.C., Spencer, R.M., and Knudsen, T.B. (2016). Computational Modeling and Simulation of Genital Tubercle Development. Reproductive Toxicology. DOI: 10.1016/j.reprotox.2016.05.005. pdf
Armfield, B.A., Seifert, A.W., Zheng, Z., Merton. E.M., Rock, J.R., Lopez C., Baker H.V., and Cohn, M.J. (2016). Molecular Characterization of the Genital Organizer: Gene Expression Profile of the Mouse Urethral Plate Epithelium. Journal of Urology. DOI: 10.1016/j.juro.2016.04.091. pdf
Gawriluk, T. R. Simkin, J., Thompson, K.L., Biswas, S., Clare-Salzler, Z., Kimani, J.M., Kiama, S.G., Ezenwa V.O., Smith, J.J., and †Seifert, A.W. (2016). Comparative analysis of ear-hole closure identifies epimorphic regeneration as a discrete trait in mammals. Nat. Commun. 7:11164 doi: 10.1038/ncomms11164. pdf
Haughton, C.L., Gawriluk, T.R., and †Seifert, A.W. (2016). The African spiny mouse (Acomys cahirinus): biology and husbandry of a laboratory colony. JAALAS. pdf
Gredler, M. L., Seifert, A. W., and Cohn, M. J. (2015). Tissue-specific roles of Fgfr2 in development of the external genitalia. Development 142 (12), 2203-2212. pdf
Maden, M., Avila, D., Roy, M., and Seifert, A.W. (2015). Tissue specific reactions to positional discontinuities in the regenerating axolotl limb. Regeneration. DOI: 10.1002/reg2.35. pdf
Gredler, M. L., Seifert, A. W., and Cohn, M. J. (2014). Phallus and cloaca development in the American alligator, Alligator mississippiensis. Journal of Sexual Development. pdf
†Seifert, A.W., and Maden, M. (2014). New insights into skin regeneration. International Review of Cell and Molecular Biology. 310, 129-169. pdf
Monaghan, J. R.*, Stier, A.C.*, Michonneau, F.*, Smith, M.D.*, Pasch, B.*, Maden, M and Seifert, A. W. *. (2014). Experimentally induced metamorphosis in axolotls reduces regenerative rate and fidelity and impedes limb regeneration in salamanders. Regeneration. 1:1, 2-14. pdf
†Seifert, A.W., and Voss, S.R. (2013). Commentary: Revisiting the relationship between regenerative ability and aging. BMC Biology, Jan 21; 11:2. pdf
†Seifert, A.W., Kiama, S.G., Seifert, M.G., Goheen J., Palmer, T. M., and Maden, M. (2012). Skin shedding and tissue regeneration in African spiny mice (Acomys). Nature, Sep 27;489(7417):561-5. pdf
Monaghan, J. R., Athippozhy, A., Seifert, A.W., Putta, S., Stromberg, A., Maden, M., Gardiner, D. M., and Voss, S. R. (2012). Gene expression patterns specific to the regenerating limb of the Mexican axolotl. Biology Open, Oct 15;1(10):937-48. pdf
†Seifert, A.W., Monaghan, J.R., Voss, S.R., and Maden, M. (2012). Skin regeneration in adult axolotls: A blueprint for scar-free healing in vertebrates. PLoSOne 7(4):e32875. Epub, Apr 2
†Seifert, A.W., Monaghan, J.R., Smith, M.D., Pasch, B., Stier, A.C., Michoneau, F., and Maden, M. (2012). The influence of fundamental traits on mechanisms controlling appendage regeneration. Biol Rev Camb Philos Soc. 2012 May;87(2):330-45. pdf
Seifert, A.W*., Zheng, Z*, Ormerod, B.K., and Cohn, M.J. (2010). Shh controls growth of external genitalia by regulating cell cycle kinetics. Nature Communications 1(3):1-9. pdf
Seifert, A.W., Bouldin, C., Choi, K.S., Harfe, B.H., and Cohn, M.J., (2009). Multiphasic and tissue specific roles for Shh during anogenital development. Development 136 (23):3949-57. pdf
Seifert, A.W., Yamaguchi, T., and Cohn, M.J. (2009). Functional and phylogenetic analysis shows that Fgf8 is a marker of genital induction in mammals but is not required for external genital development. Development 136(15):2643-51. pdf
Seifert, A.W., Harfe, B.H., and Cohn, M.J. (2008). Cell lineage analysis demonstrates an endodermal origin of the distal urethra and perineum. Developmental Biology 1;318(1):143-52. (cover article) pdf
Seifert, A.W., and Chapman, L.J. (2007). The relationship between temperature and standard rate of metabolism in the African lungfish Protopterus aethiopicus, from Uganda. African Journal of Aquatic Sciences, 32(3) 299-303. pdf
Garner, S., Birt, T.P., Mlewa, C.M., Green, J.M., Seifert, A., and Friesen, V.L. (2006). Genetic variation in the marbled lungfish Protopterus aethiopicus in Lake Victoria and introduction to Lake Baringo, Kenya. Journal of Fish Biology, 69: 189-199.
Seifert, A.W., and Chapman, L.J. (2006). Respiratory allocation and standard rate of metabolism in the African lungfish, Protopterus aethiopicus. Comparative Biochemistry and Physiology: Molecular and Integrative Physiology, 143(1):142-8. pdf
Chapman, L.J., Nordlie, F.G., and Seifert, A. (2002). Respiratory oxygen consumption among groups of the African cichlid Pseudocrenilabrus multicolor victoriae subjected to different oxygen concentrations during development. Journal of Fish Biology, 61: 242-251. pdf
Book Chapters, Edited Volumes, Technical Reports
†Seifert, A.W. and Currie, J. (2022). Editors. Salamanders. Methods in Molecular Biology. vol 2562. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2659-7_5
Purushothaman S., Seifert A.W. (2022). Whole-Mount In Situ Hybridization (WISH) for Salamander Embryos and Larvae. Methods Mol Biol. 2023; 2562:95-107. doi: 10.1007/978-1-0716-2659-7_5.
†Seifert, A.W. and Temple-Smith, P. (2021). A remarkable rodent: regeneration and reproduction in spiny mice (Acomys). Current Topics in Developmental Biology, 147, 659-707.
†Seifert, A.W. (2017). Comparative Regeneration. Developmental Cell 43. p. 373. pdf doi.org/10.1016/j.devcel.2017.11.009
Coots, P., and †Seifert, A.W. (2015). Thyroxine induced metamorphosis in the axolotl (Ambystoma mexicanum). In, Salamanders in Regeneration Research in Methods in Molecular Biology, eds. Kumar, A. and Simon, A. Springer. USA. pp. 141-145. pdf
Ankerson, T.T., Fernandez, S., M., Seifert, A.W., and Velez, M.V. (2003). The gopher tortoise and upland habitat protection in Florida: Legal and policy considerations. In, Report on protected species and habitat protection, Ankerson, T.T., Fernandez, S.M., and Seifert, A.W. (eds). Report available through UF Levin College of Law library.
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